Evaluation of Fine-needle Aspiration Cytology (FNAC) Sensitivity Compared to PCR for Diagnosing Tuberculosis Lymphadenitis

Background: Tuberculosis (TB) is a major healthcare burden in Sudan and other developing countries, it considered the second most common cause of death from infectious diseases after those due to AIDS. In Sudan, TB lymphadenitis (TBLA) remains one health problems. This descriptive cross-sectional study was conducted at University Medical Sciences Technology (UMST) Total Labcare Diagnostic Center (TDC). The aims compare sensitivity Fine Needle Aspiration Cytology (FNAC) smears with that Polymerase Chain Reaction (PCR) for diagnosis TBLA.
 Materials Methods: Fifty-five dry were obtained using fine-needle aspiration (FNA) an enlarged lymph node. PCR applied detect target gene (IS6110). May-Grunwald-Giemsa (MGG) or Diff quick stains used.
 Results: Two (4%) patients TBLA non-necrotic, while fifty-three them (96%) necrotic. Moreover, 17 (30%) node specimens confirmed by be positive Mycobacterium tuberculosis complex (MTB complex) 38 (70%) negative.
 Conclusion: There no significant difference between FNAC (P-value = 0.33).